Parallel tolerance between platelet cyclic GMP and preload effects of nitroglycerin in anaesthetized mini-pigs

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Platelet Cyclic GMP

Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 1994

ISSN: 0007-1188

DOI: 10.1111/j.1476-5381.1994.tb16900.x